CDPA + CDDY
Chondrodysplasia (CDPA) is a short-legged phenotype characteristic of many dog breeds. Chondrodystrophy, a separate mutation, also includes a short-legged phenotype as well as susceptibility to intervertebral disc disease.
Chondrodystrophy (CDDY), caused by a separate mutation, also includes a short-legged phenotype as well as abnormal premature degeneration of intervertebral discs leading to susceptibility to intervertebral disc herniation. Almost ALL French Bulldogs carry both copies for this. Rarely you will be able to find one with only ONE copy.
Canine Multifocal Retinopathy 1 (CMR1) is an inherited eye disease caused by a mutation (c.73C>T) in the Bestrophin 1 gene that results in a shortened, dysfunctional protein. Affected dogs typically present with multiple, discrete circular areas of retinal detachment between 11 and 16 weeks of age.
Juvenile Hereditary Cataracts (JHU) are an inherited form of cataracts that commonly cause blindness in dogs by clouding the lens of the eye and affecting both eyes symmetrically.
Hyperuricosuria (HUU) is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.
Cystinuria Type III
Cystinuria Type III is an inherited disease affecting kidney function in dogs. Dogs with Cystinuria are deficient in a specific protein that is essential for the transport of Cystine and other amino acids from urine. Normal kidneys reabsorb Cystine so that only small amounts pass into the urine. However, dogs with Cystinuria fail to reabsorb Cystine, allowing large amounts to pass into the urine. Excessive Cystine can form crystals and/or stones in the urinary tract, which can block the ureters or urethra and stop the normal flow of urine.